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Acomplia (Rimonabant) diet drug is a prescription medicine indicated for obesity, its Active Ingredient is: Rimonabant. Its Manufacturer Approvals: US FDA, WHO, UK MCA. Acomplia (Rimonabant) is an oral-prescription drug which is to be taken once in a day, before breakfast with one full glass of water.

GENERIC XENICAL (Alli) Diet Drug is a prescription medication indicated for weight loss, its Active Ingredient: Orlistat.

If you are considering starting a weight loss plan with the use of Phentermine you have several ways to obtain this prescription medication but the viable alternative to get this weight loss aid is to visit the doctor’s office. Your family doctor will study your other medical conditions and possible medication interactions that you may face during the use of Phentermine. Phentermine should be carefully thought out before you start the use of this medication.You should inform your family doctor if you are pregnant, nursing, or are thinking about getting pregnant; if you have high blood pressure, heart or liver conditions. You should take into account your doctor’s expertise when considering using Phentermine along with taking any other type of medication.  Your physician plays an important role in taking your weight loss decisions because you can talk to him face to face, he may have additional literature you can read, and he can tell you about interactions with the medications you are currently taking. Consulting your doctor, you should consider the setting of the weight loss goals to achieve the best personal outcomes possible.

Phentermine works on the hypothalamus portion of the brain to release norepinephrine, a neurotransmitter or chemical messenger that signals a fight-or-flight response, reducing hunger. Phentermine works outside the brain as well to release epinephrine or adrenaline causing fat cells to break down stored fat, but the principal basis of efficacy is hunger-reduction. At high doses, phentermine releases serotonin and dopamine as well, but such doses are never used in clinical medicine.

Dosing and administration

Generally, it is recommended by the Food and Drug Administration (FDA) that phentermine should be used short-term (usually interpreted as ‘up to 12 weeks’), while following nonpharmacological approaches to weight loss such as healthy dieting and exercise.

Contraindications and warnings

• Patients with the following should not use Phentermine:
  • An allergy to any ingredient in Phentermine or other sympathomimetics (e.g., pseudoephedrine)
  • Are also taking dexfenfluramine, fenfluramine, furazolidone, guanadrel, guanethidine, or have taken a monoamine oxidase inhibitor (MAOI) (e.g., phenelzine, ayahuasca) in the last 14 days
  • Have severe high blood pressure, an overactive thyroid, glaucoma, heart or blood vessel disease, or severe narrowing of the blood vessels
  • Are in an agitated state, or have a history of substance abuse
• Some medical conditions may interact with Phentermine, patients with the following should consult with their doctor before using phentermine:
  • Are pregnant, planning to become pregnant, or are breast-feeding
  • Are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • Have allergies to medicines, foods, or other substances
  • Have a brain or spinal cord disorder, hardening of the arteries, high blood pressure, diabetes, or high cholesterol or lipid levels
• Some medicines may interact with phentermine, such as the following:
  • Dexfenfluramine, fenfluramine, furazolidone, or MAOIs (e.g., phenelzine) because the risk of serious side effects, such as increasing headache, high blood pressure, slow heart rate, elevated temperature, or possibly fatal lung problems, may be increased
  • Guanadrel(Hylorel) or guanethidine(Ismelin) because their effectiveness may be decreased by phentermine
  • Antacids: Antacids may decrease the excretion of phentermine.
  • Carbonic anhydrase inhibitors (acetazolamide, dichlorphenamide, methazolamide): Carbonic anhydrase inhibitors may decrease the excretion of phentermine.

Phentermine – Clinical Pharmacology

Phentermine hydrochloride is a sympathomimetic amine with pharmacologic activity similar to the prototype drugs of this class used in obesity, the amphetamines. Actions include central nervous system stimulation and elevation of blood pressure. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class in which these phenomena have been looked for.

Drugs of this class used in obesity are commonly known as “anorectics” or “anorexigenics.” It has not been established that the action of such drugs in treating obesity is primarily one of appetite suppression. Other central nervous system actions, or metabolic effects, may be involved, for example.

Adult obese subjects instructed in dietary management and treated with “anorectic” drugs lose more weight on the average than those treated with placebo and diet, as determined in relatively short-term clinical trials.

The magnitude of increased weight loss of drug-treated patients over placebo-treated patients is only a fraction of a pound a week. The rate of weight loss is greatest in the first week of therapy for both drug and placebo subjects and tends to decrease in succeeding weeks. The possible origins of the increased weight loss due to the various drug effects are not established. The amount of weight loss associated with the use of an “anorectic” drug varies from trial to trial, and the increased weight loss appears to be related in part to variables other than the drug prescribed, such as the physician-investigator, the population treated and the diet prescribed. Studies do not permit conclusions as to the relative importance of the drug and non-drug factors on weight loss.

The natural history of obesity is measured in years, whereas the studies cited are restricted to a few weeks’ duration; thus, the total impact of drug-induced weight loss over that of diet alone must be considered clinically limited.

Before taking phentermine

Do not use phentermine if you have taken an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) in the last 14 days. Serious, life threatening side effects can occur if you use phentermine before the MAO inhibitor has cleared from your body.

Taking phentermine together with other diet medications such as fenfluramine (Phen-Fen) or dexfenfluramine (Redux) can cause a rare fatal lung disorder called pulmonary hypertension. Do not take tbis medicine with any other diet medications without your doctor’s advice.

You should not take phentermine if you are allergic to it, or if you have:

• coronary artery disease (hardening of the arteries);
• heart disease;
• severe or uncontrolled high blood pressure;
• overactive thyroid;
• glaucoma;
• if you have a history of drug or alcohol abuse; o
• if you are allergic to other diet pills, amphetamines, stimulants, or cold medications.

If you have any of these other conditions, you may need a phentermine dose adjustment or special tests:

• high blood pressure;
• diabetes; or
• a thyroid disorder.

FDA pregnancy category C. It is not known whether phentermine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Phentermine can pass into breast milk and may harm a nursing baby. You should not breast-feed while taking phentermine. Do not give this medication to a child younger than 16 years old.

Phentermine may be habit-forming and should be used only by the person it was prescribed for. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.

How should I take phentermine?

Take phentermine exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

It is best to take phentermine on an empty stomach before breakfast or within 2 hours after breakfast.

To prevent sleep problems, take this medication early in the day, no later than 6:00 pm.

Talk with your doctor if you have increased hunger or if you otherwise think the medication is not working properly. Taking more of this medication will not make it more effective and can cause serious, life-threatening side effects.

Phentermine should be taken only for a short time, such as a few weeks.

Do not stop taking phentermine suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using phentermine.

Store at room temperature away from moisture and heat.

Keep track of the amount of medicine used from each new bottle. Phentermine is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.